What is a Clinical Research Associate (CRA) job all about?

Many people trying to obtain their first job in the pharmaceutical industry have a particular role in mind: the Clinical Research Associate, or CRA. These positions are seen as desirable because they typically offer relatively high salaries, a lot of independence, and are frequently home-based. In this post, I’m going to discuss the Clinical Research Associate’s role in detail: what do CRAs actually do? How does one obtain a CRA job? And what are the long-term career prospects for a new CRA?

As the name suggests, a Clinical Research Associates’s role in drug development begins at the clinical research stage, which is the point when human testing begins. CRAs may be involved with Phase I, II, III, or IV (post-marketing) clinical trials. A CRA’s main responsibility is to monitor clinical trials (and in fact some companies refer to CRAs as clinical research monitors). A CRA will travel to the clinical sites where trials are being conducted to ensure that all of the activity relating to the trial is in compliance with the protocol and ICH-GCP (Good Clinical Practice) guidelines. This may include reviewing the way patients are enrolled, to ensure that they meet the inclusion criteria; checking that clinical trial supplies are stored and dispensed appropriately; and reviewing Case Report Forms (CRFs) to ensure that they have been filled out correctly. In many ways, the CRA’s job is one of quality control, and many of the best CRAs pride themselves on having an extremely detail-oriented, “checklist mentality”. Of course, sometimes a site visit will reveal problems, and at that point the CRA must work with the staff on site to resolve outstanding issues. This can sometimes require a lot of charm and good negotiation skills!

Clinical Research Associates are frequently home-based, which is one reason that many people see this role as desirable, but this must be balanced against the fact that CRAs spend a great deal of time away from home. A CRA will typically be responsible for 5-10 different clinical sites, and will visit each one several to many times during a trial at a frequency determined by the protocol. This means that many CRAs are constantly on the road, and can expect to be away from home 60-80% of the time. Those working in urban centres may be able to drive to their sites, but regional CRAs must often fly to more distant locations. Many CRAs find the frequent travel exhausting after a few years of experience.

Historically, the major pharmaceutical companies that sponsor drug trials have been the largest employers of Clinical Research Associates, but this is beginning to change. Increasingly, these companies are outsourcing the operational aspects of the clinical trial process. Contract research organizations (CROs) such as Quintiles, Kendle, and ICON carry out trial activities on behalf of the sponsors. As a result, these days there are many more CRA jobs available with CROs than there are directly available with pharmaceutical companies. Many experienced CRAs choose to work independently, as self-employed contractors, working for a sponsor or CRO for the duration of a trial.

Working as a CRA for a Contract Research Organization can be different than working directly for a sponsor. In this position, CRAs often gain experience in many different therapeutic areas and work with many different protocols, which can be valuable for career development. However, they may also be required to monitor several different trials at the same time, which can be stressful. In contrast, CRAs working directly for sponsors sometimes complain because they are asked to monitor sites over much larger geographic areas, which can increase the amount of time they are away from their homes and families.

The Clinical Research Associate marketplace has been very competitive. Because CRAs are very much in demand, and their role is virtually identical in every company, it is easy for them to change jobs. CRAs are frequent targets of headhunters. As a result, companies have offered high salaries and excellent benefits in an attempt to buy employee loyalty. The pharmaceutical companies have typically offered higher salaries than CROs, but the shift in the marketplace towards outsourcing may be changing the dynamics of CRA compensation. Currently, a qualified CRA with less than 2 years of experience might reasonably expect to earn a base salary of about $60,000 and will see their salary potential grow quickly. It is not unusual to see CRAs with 3 years of experience earning in excess of $85,000. CRA compensation frequently also includes a company car and a competitive bonus structure. A CRA’s salary will normally max out at about $95,000. CRAs who go into business for themselves as self-employed contractors typically bill their services at $65-$100 per hour.

Many CRAs greatly enjoy their jobs and are happy to remain as clinical research monitors for their entire careers. Those who are looking for career development will typically move towards project management, becoming responsible for organizing a team of CRAs and managing operational aspects of trials. This in turn can lead towards senior roles in Clinical Operations.

To be hired as a Clinical Research Associate these days, an individual normally must have a degree in health sciences or life sciences. Many companies prefer to hire people with a Nursing background because of their familiarity with clinical settings. A very strong knowledge of ICH-GCP guidelines is essential. In terms of personality, a successful CRA must balance strong people skills with a very detail-oriented checklist mentality. It may be easier to get your foot in the door by starting as a clinical research assistant, or clinical trial associate instead. I’ll talk about this role in more detail in a future article.

Because CRA jobs are in demand, many courses and programs have appeared claiming to offer training that will help new job-seekers to obtain them. A number of colleges now offer post-graduate programs in clinical research that are respected by the industry; these frequently include co-op opportunities that give students real, on-the-job experience in clinical monitoring. In contrast, there are also many online courses and less reputable programs that will take students’ money, offer cursory training in ICH-GCP, and give graduates a certificate that is nearly worthless on the job market. One notorious company bills itself as a CRO, posts jobs online, and then steers applicants towards its expensive ‘training program’.  Unfortunately, having this company’s certificate listed on your resume is evidence of poor judgement, not good clinical training. Before spending any money on training programs, it’s important to do extensive research to ensure that you’re not getting ripped off.

Posted: October 28th, 2008 | Author: | Filed under: Clinical research, Clinical Research Associates, ICH-GCP | Tags: , , , , , , , , | 24 Comments »

24 Comments on “What is a Clinical Research Associate (CRA) job all about?”

  1. 1 CRA training: How NOT to conduct a site visit | Your First Pharma Job said at 6:16 pm on January 27th, 2009:

    […] can read more about what a CRA job is all about in this earlier article. Share this […]

  2. 2 abigail said at 4:37 pm on November 22nd, 2010:

    thank you for this, this was really helpful

  3. 3 get best rolex said at 8:06 pm on July 25th, 2013:

    Try to buy your watchfulness only from a website that has a tax free compute. You must bridle if the compute is working, because fraudsters put up the compute only to make clan believe that the website is sure. Term on the given compute and talk with articulate sounds to any symbolical and ask a few questions about the watchfulness you intend to buy. If you imagine any stained caper while speaking to the symbolical, proximately birch to another website.

  4. 4 Garland said at 1:06 pm on July 3rd, 2014:

    Hey there! Do you use Twitter? I’d like to follow you if
    that would be okay. I’m absolutely enjoying your blog and look forward to new updates.

    Here is my web blog: how much is yours worth? (Garland)

  5. 5 Sara said at 7:29 pm on May 2nd, 2015:

    Thanks for the detailed answer to my all the queries. Very well written!

  6. 6 Patrickreet said at 12:47 am on April 28th, 2016:

    online hotel booking in johannesburg airfare american croatia airlines dd united airlines flight bag jr airport express haruka flights etihad australia flights cpt to bloemfontein flights into lmt cheap airline tickets to glasgow scotland cheap flights iad to lhr lufthansa eritrea flights
    airline fuel charge lwc airport flight information fiji airline fee yr airports pyrenees france cheapest tickets from chicago airlines sfb discount airfare spirit thomson airways flight bookings discount tickets nrh2o cheap flights lhr to cdg discount ticket booth london cheap airline tickets to victoria bc southwest airlines minneapolis flights delta airlines flight attendants facebook
    flights using avios delta airlines new flights airline hjul airfare mke to hawaii american airlines ticket center final return due date cra airline mogul tips lufthansa airline ticket number american airlines rude flight attendant airline no baggage fees airline zy sitzplatzreservierung airlines surfboard fees
    qxe airline code cheap tickets portaventura airfare to ubud bali american airlines flights la to nyc airports albuquerque nm discount ticket zip delta airlines flight attendant open house airport bqn puerto rico airports killington vt airport darwin airfare italy to greece airports meribel

  7. 7 Patrickreet said at 12:18 am on May 5th, 2016:

    buy tickets online galaxy saskatoon ieagle airfare airline mro industry emirates airlines flight arrivals sydney bsp flights flights smf to cancun flights bkk to singapore united airlines special fares flights luton to dublin flights volos to london cheap air tickets rs 99
    flights ottawa to florida ufb airline rewards checking return date garnishment community return date season 4 fda airlines cheap flights uluru to melbourne lufthansa flights manchester to frankfurt airports dayton ohio airline deals to florida book cheap flights pakistan hernandez return date flight information philippines wgtn airport departures airfare nc fhr airport lounges
    jquery airport ticker airline duty of care cheap tickets fiesta texas southwest airlines ticket cancellation policy jst flights cheapest air tickets worldwide united airlines flights out of dulles delta airlines direct flights cheap tickets portland oregon flight status pune airport flights darwin to melbourne airfare from ghana to india
    cheap tickets piano guys airport wds relay vs remote discount airfare japan domestic airport rome ciampino airport dzihan kamien airfare apex discount tickets fuerza bruta airports in nd usa airports ios app cheap flights eze to lax japan airlines jr pass airport lbv

  8. 8 thepushkin said at 1:04 am on August 31st, 2016:

    Enter comment here.

  9. 9 nannieia3 said at 6:25 am on December 2nd, 2016:

    Started untrodden snare project
    free dating apps bike game android download sexy video downlod internet filtering software free mobile apps for mobile
    download video of sexy girls cost of android app development free tv streaming android music apps android best android app apk

  10. 10 HectorEi said at 2:16 pm on December 6th, 2016:

    dump forum – cc dumps shop, dumps sites.

  11. 11 MichelMig said at 4:02 pm on February 10th, 2017:

    ???? ????? ?????? – ???????????? ??????????? ???????????? .
    ??? ????????????, ??? ?? ??????? ????????? ????? ?? ??, ??? ???????? ?????? ???? ??? ?? ????? ?? ?????? ?????.
    ?????? ????????? ??????????, ??? ???? 5% ??????? ?????? ????? ?? ????.
    ?????? ??? ???????????
    ?? ?????? ??? ??????? ???????? ???????? ????? ????? ?? ?????? ?????.
    ? ???? ??????? ???? ?????????? ?????????? ??? ???????????? ??????????? ???????????? ??????? – ??? ????? ??? ???????????.
    ??? ?????????? ??? ??????? ????? ??????????, ????? ???? ??? ?????????? ?? ?????? ????????????? ???? ??????????? ????.
    ??? ??????? “?? ???????????? ???????”, ????? ????, ??? ?? ????????? ??? ?????? ????????.
    ???????, ??? ?????????? ?? ??? ????????? ? ???????? ???????, ?????? ?????????? ?? ??? ?????????? ?????? ????????? ????.
    ??? ???????? ???? ??????
    ? ???????? ???????? ?????? ? ???????????? ?????? ????? ??????, ?????? ?????? ? ???????: “???????????? ??????????? ????????????”.
    ? ?????? ????????????, ? ?? ???????????.


  12. 12 VideoPortal said at 2:27 am on March 30th, 2017:

    Being a CCRA makes me a better clinical researcher and that’s a really great feeling. Certification means I’m an accomplished professional with the knowledge needed to lead and inspire world-class teams of researchers.

  13. 13 Denniscet said at 9:09 am on March 31st, 2017:

    ???? ??????????? ? ???????? ?????? ?????? – ????? ????????????? ????????? ???????? ??? ??? ??????. ?????? ???????? ???? ?????? ??????? ?????? ???? ??????? ??????????? ??????.
    ?? ??????????? ???? ????? ????????????? ????? ?? ??????? ?????? ?? ?????? ????????? ??. ? ?????? ?? ?????? ??????? ? ???????????, ?????????? ??????????? ??????? ? ?????????? ??????? ??????????? ?????????? ???????? ?? ?????? ????? – ???? ?? ???????.
    ? ???????, ?????? ??????? ??????? ???? ???????? ????????? ???????? ????????????? ???????????? ???????????? (???), ??????? ???? ??????????? ?? ?????????????? ????? ?????????? ????? ?? ???????????? ???????????? ? ????????.
    ? ?????????, ?? ?????? ??????????? ? ???????? ?????? ? ?? ????????? ???????? ????????? ??????????, ???????? ?????????? ????? ? ???????? ? ????????????? ?? ????????? ??????? ?????????.
    ? ????????? ????????????? ???????????? ???????????? ??? ????? ???? ???????????:
    ” ????????? ???????? ?????????? ???? ?? ????? ?? ????????;
    ” ????????? ????????????? ? ?????? ?????? ?????????;
    ” ????????? ??? ?? ??????? ???????????? ???????? ????????? ? ???????????;
    ” ?????? ?????? ????????????, ??????????? ? ??? ????????.
    ????? ???????????? ?? ??????? ?????? ? ????????? ?????????????? ??????? ?????????? ???????? ? ????? ??????? ??? Google ???????? ?????????: “???????????? ??????????? ????????????”. ????? ????? ??????? ????? ?????????????? ??????? ? ???????? ???????.


  14. 14 Payal Pawar said at 3:54 am on November 20th, 2017:

    Great Post !!

    This blog post of yours was a value addition for me. I really liked your writing style. you explained everything about Clinical Research Associate Job in very well manner. I am glad that you simply shared this helpful information with us.
    /Thanks for sharing!!

  15. 15 jocelynao11 said at 7:51 am on January 17th, 2018:

    Updated contrive sheet:

  16. 16 alvinqc1 said at 9:25 am on January 20th, 2018:

    My new website:

  17. 17 williamsw69 said at 8:58 pm on February 20th, 2018:

    New domestic page instead of beetle out:

  18. 18 luannsj11 said at 5:17 pm on March 17th, 2018:

    Updated contrive call:

  19. 19 JerryEngef said at 10:33 am on March 22nd, 2018:

    Enter comment here.

  20. 20 rosiepn3 said at 6:24 pm on April 5th, 2018:

    Assignment servant moved:

  21. 21 matildacz11 said at 6:33 pm on April 19th, 2018:

    Updated project page:

  22. 22 billysy60 said at 7:29 pm on June 4th, 2018:

    Proposal attendant moved:

  23. 23 UXAMWEGFWICPYCAJ said at 2:44 pm on August 29th, 2018:

    Nice read, I just passed this onto a colleague who was doing some research on that. And he actually bought me lunch as I found it for him smile So let me rephrase that: Thank you for lunch!

  24. 24 Diana David said at 9:11 pm on March 31st, 2020:

    It’s apparent that the author is a data geek. I like the way he writes and organizes facts.
    It is always such a pleasure to read articles
    created by real professionals, like https://rodeo-club.net/lessons-at-the-midpoint/. I’m fed up with that no-name,
    ghostwritten articles. That’s why it was so nice to have
    a look at a compelling piece. I see the author has ground knowledge it the topic in addition to some practical experience.

    Such kind of information is always more valuable than copypasted blog posts ideas.

Leave a Reply